Phthalate Exposure and Neurotoxicity in Children: A Systematic Review and Meta-analysis

This systematic review aims to assess the relationship between prenatal and childhood exposure to phthalates and neurodevelopmental outcomes, identifying periods of heightened susceptibility. Data sou...

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Association between Emission Parameters and Material-phase Concentrations of Phthalate Plasticizers and their Alternatives

ABSTRACT Plasticizers are frequently used in building materials and consumer products and many are semi-volatile organic compounds (SVOCs). Understanding the emission rate of plasticizers in indoor e...

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A rapid micro chamber method to measure SVOC emission and transport model parameters

ABSTRACT Assessing exposure to semivolatile organic compounds (SVOCs) that are emitted from consumer products and building materials in indoor environments is critical for reducing the associated hea...

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Development, testing, parameterisation, and calibration of a human PBPK model for the plasticiser, di-(2-ethylhexyl) terephthalate (DEHTP) using in silico, in vitro and human biomonitoring data

ABSTRACT A physiologically based pharmacokinetic model for di-(2-ethylhexyl) terephthalate (DEHTP) based on a refined model for di-(2-propylheptyl) phthalate (DPHP) was developed to interpret the m...

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Development, Testing, Parameterisation & Calibration of a Human PBPK Model for DPHP

ABSTRACT A physiologically based pharmacokinetic model for Di-(2-propylheptyl) phthalate (DPHP) was developed to interpret the biokinetics in humans after single oral doses. The model was parameter...

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Systematic comparison of the male reproductive tract in fetal and adult Wistar rats exposed to DBP and DINP in utero during the masculinisation programming window

ABSTRACT This study investigates possible effects of in utero exposure of rats to a low dose (125 mg/kg bw/day) and a high dose (750 mg/kg bw/day) of Diisononyl phthalate (DINP) during the masculin...

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Development of a physiologically based pharmacokinetic model of diisononyl phthalate (DiNP) in pregnant rat and human

ABSTRACT   A physiologically based pharmacokinetic (PBPK) model for di-isononyl phthalate (DiNP) was developed by adapting the existing models for di(2-ethylhexyl) phthalate (DEHP) and di-but...

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Plasticisers chapter in Ullmann’s Encyclopedia of industrial chemistry

Discover the main used plasticisers and their applications in Ullmann's Encyclopedia of industrial chemistry.   Read more about the contribution of European Plasticisers to the Encyclopedia h...

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Study of a Human Physiologically Based Pharmacokinetic Model for the Plasticiser, Hexamoll® DINCH

Development, Testing, Parameterization, and Calibration of a Human Physiologically Based Pharmacokinetic Model for the Plasticizer, Hexamoll® Diisononyl-Cyclohexane-1, 2-Dicarboxylate Using In Silico...

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FACTSHEET – A Quantitative Weight of Evidence Methodology (QWoE)

Learn more about the methodology developed by Professors W. Dekant and J.Bridges to make scientific evaluations more consistent when testing a hypothesis, using predefined criteria. Our factsheet allo...

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A QWoE methodology for the assessment of reproductive and developmental toxicity and its application for classification and labeling of chemicals

ABSTRACT Hazard assessment of chemicals usually applies narrative assessments with a number of weaknesses. Therefore, application of weight of evidence (WoE) approaches are often mandated but gui...

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Assessment of reproductive and developmental effects of DINP, DnHP and DCHP using quantitative weight of evidence

ABSTRACT Quantitative weight of evidence (QWoE) methodology utilizes detailed scoring sheets to assess the quality/reliability of each publication on toxicity of a chemical and gives numerical scores...

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Outcome reporting bias in observational epidemiology studies on phthalates

Introduction Phthalates are used in cosmetics, flooring adhesives, medical tubings, toys, food packaging materials, and so forth. A number of reviews of the epidemiology of phthalates have been publi...

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European Plasticisers concludes LCA study on DINP

INTRODUCTION European Plasticisers (formerly European Council for Plasticisers and Intermediates - ECPI) commissioned PE International to conduct an LCA study with the goal to setup a PlasticsEurope...

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