Science

28/10/2020

Systematic comparison of the male reproductive tract in fetal and adult Wistar rats exposed to DBP and DINP in utero during the masculinisation programming window

ABSTRACT This study investigates possible effects of in utero exposure of rats to a low dose (125 mg/kg bw/day) and a high dose (750 mg/kg bw/day) of Diisononyl phthalate (DINP) during the masculin...

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11/08/2020

Development of a physiologically based pharmacokinetic model of diisononyl phthalate (DiNP) in pregnant rat and human

ABSTRACT   A physiologically based pharmacokinetic (PBPK) model for di-isononyl phthalate (DiNP) was developed by adapting the existing models for di(2-ethylhexyl) phthalate (DEHP) and di-but...

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04/06/2020

Plasticisers chapter in Ullmann’s Encyclopedia of industrial chemistry

Discover the main used plasticisers and their applications in Ullmann's Encyclopedia of industrial chemistry.   Read more about the contribution of European Plasticisers to the Encyclopedia h...

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31/10/2019

Study of a Human Physiologically Based Pharmacokinetic Model for the Plasticiser, Hexamoll® DINCH

Development, Testing, Parameterization, and Calibration of a Human Physiologically Based Pharmacokinetic Model for the Plasticizer, Hexamoll® Diisononyl-Cyclohexane-1, 2-Dicarboxylate Using In Silico...

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04/01/2017

FACTSHEET – A Quantitative Weight of Evidence Methodology (QWoE)

Learn more about the methodology developed by Professors W. Dekant and J.Bridges to make scientific evaluations more consistent when testing a hypothesis, using predefined criteria. Our factsheet allo...

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01/12/2016

A QWoE methodology for the assessment of reproductive and developmental toxicity and its application for classification and labeling of chemicals

ABSTRACT Hazard assessment of chemicals usually applies narrative assessments with a number of weaknesses. Therefore, application of weight of evidence (WoE) approaches are often mandated but gui...

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01/11/2016

Assessment of reproductive and developmental effects of DINP, DnHP and DCHP using quantitative weight of evidence

ABSTRACT Quantitative weight of evidence (QWoE) methodology utilizes detailed scoring sheets to assess the quality/reliability of each publication on toxicity of a chemical and gives numerical scores...

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01/07/2016

Outcome reporting bias in observational epidemiology studies on phthalates

Introduction Phthalates are used in cosmetics, flooring adhesives, medical tubings, toys, food packaging materials, and so forth. A number of reviews of the epidemiology of phthalates have been publi...

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01/01/2015

European Plasticisers concludes LCA study on DINP

INTRODUCTION European Plasticisers (formerly European Council for Plasticisers and Intermediates - ECPI) commissioned PE International to conduct an LCA study with the goal to setup a PlasticsEurope...

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