Science
Development, testing, parameterisation, and calibration of a human PBPK model for the plasticiser, di-(2-ethylhexyl) terephthalate (DEHTP) using in silico, in vitro and human biomonitoring data
ABSTRACT A physiologically based pharmacokinetic model for di-(2-ethylhexyl) terephthalate (DEHTP) based on a refined model for di-(2-propylheptyl) phthalate (DPHP) was developed to interpret the m...
Read moreDevelopment, Testing, Parameterisation & Calibration of a Human PBPK Model for DPHP
ABSTRACT A physiologically based pharmacokinetic model for Di-(2-propylheptyl) phthalate (DPHP) was developed to interpret the biokinetics in humans after single oral doses. The model was parameter...
Read moreSystematic comparison of the male reproductive tract in fetal and adult Wistar rats exposed to DBP and DINP in utero during the masculinisation programming window
ABSTRACT This study investigates possible effects of in utero exposure of rats to a low dose (125 mg/kg bw/day) and a high dose (750 mg/kg bw/day) of Diisononyl phthalate (DINP) during the masculin...
Read moreDevelopment of a physiologically based pharmacokinetic model of diisononyl phthalate (DiNP) in pregnant rat and human
ABSTRACT A physiologically based pharmacokinetic (PBPK) model for di-isononyl phthalate (DiNP) was developed by adapting the existing models for di(2-ethylhexyl) phthalate (DEHP) and di-but...
Read morePlasticisers chapter in Ullmann’s Encyclopedia of industrial chemistry
Discover the main used plasticisers and their applications in Ullmann's Encyclopedia of industrial chemistry. Read more about the contribution of European Plasticisers to the Encyclopedia h...
Read moreStudy of a Human Physiologically Based Pharmacokinetic Model for the Plasticiser, Hexamoll® DINCH
Development, Testing, Parameterization, and Calibration of a Human Physiologically Based Pharmacokinetic Model for the Plasticizer, Hexamoll® Diisononyl-Cyclohexane-1, 2-Dicarboxylate Using In Silico...
Read moreFACTSHEET – A Quantitative Weight of Evidence Methodology (QWoE)
Learn more about the methodology developed by Professors W. Dekant and J.Bridges to make scientific evaluations more consistent when testing a hypothesis, using predefined criteria. Our factsheet allo...
Read moreA QWoE methodology for the assessment of reproductive and developmental toxicity and its application for classification and labeling of chemicals
ABSTRACT Hazard assessment of chemicals usually applies narrative assessments with a number of weaknesses. Therefore, application of weight of evidence (WoE) approaches are often mandated but gui...
Read moreAssessment of reproductive and developmental effects of DINP, DnHP and DCHP using quantitative weight of evidence
ABSTRACT Quantitative weight of evidence (QWoE) methodology utilizes detailed scoring sheets to assess the quality/reliability of each publication on toxicity of a chemical and gives numerical scores...
Read moreOutcome reporting bias in observational epidemiology studies on phthalates
Introduction Phthalates are used in cosmetics, flooring adhesives, medical tubings, toys, food packaging materials, and so forth. A number of reviews of the epidemiology of phthalates have been publi...
Read moreEuropean Plasticisers concludes LCA study on DINP
INTRODUCTION European Plasticisers (formerly European Council for Plasticisers and Intermediates - ECPI) commissioned PE International to conduct an LCA study with the goal to setup a PlasticsEurope...
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