This systematic review aims to assess the relationship between prenatal and childhood exposure to phthalates and neurodevelopmental outcomes, identifying periods of heightened susceptibility. Data sources considered studies examining repeated phthalate exposure during pregnancy and childhood on neurodevelopment. Evaluation included bias risk and study quality criteria. Evidence...
ABSTRACT Plasticizers are frequently used in building materials and consumer products and many are semi-volatile organic compounds (SVOCs). Understanding the emission rate of plasticizers in indoor environments is critical for subsequent exposure and health risk assessments. While concerns have been increasing regarding the use of phthalate...
ABSTRACT Assessing exposure to semivolatile organic compounds (SVOCs) that are emitted from consumer products and building materials in indoor environments is critical for reducing the associated health risks. Many modeling approaches have been developed for SVOC exposure assessment indoors, including the DustEx webtool. However, the applicability...
ABSTRACT A physiologically based pharmacokinetic model for di-(2-ethylhexyl) terephthalate (DEHTP) based on a refined model for di-(2-propylheptyl) phthalate (DPHP) was developed to interpret the metabolism and biokinetics of DEHTP following a single oral dose of 50 mg to three male volunteers. In vitro and in silico methods were used to generate...
ABSTRACT A physiologically based pharmacokinetic model for Di-(2-propylheptyl) phthalate (DPHP) was developed to interpret the biokinetics in humans after single oral doses. The model was parameterized with in vitro and in silico derived parameters and uncertainty and sensitivity analysis was used during the model development process...
ABSTRACT This study investigates possible effects of in utero exposure of rats to a low dose (125 mg/kg bw/day) and a high dose (750 mg/kg bw/day) of Diisononyl phthalate (DINP) during the masculinisation programming window (MPW) which is embryonic days 15.5–18.5 (e15.5 - e18.5). Dibutyl phthalate...
ABSTRACT A physiologically based pharmacokinetic (PBPK) model for di-isononyl phthalate (DiNP) was developed by adapting the existing models for di(2-ethylhexyl) phthalate (DEHP) and di-butylphthalate (DBP). Both pregnant rat and human time-course plasma and urine data were used to address the hydrolysis of DiNP in intestinal tract,...
Discover the main used plasticisers and their applications in Ullmann's Encyclopedia of industrial chemistry. Read more about the contribution of European Plasticisers to the Encyclopedia here. You can purchase the online version of ULLMANN'S ENCYCLOPEDIA here. ...
Development, Testing, Parameterization, and Calibration of a Human Physiologically Based Pharmacokinetic Model for the Plasticizer, Hexamoll® Diisononyl-Cyclohexane-1, 2-Dicarboxylate Using In Silico, In Vitro, and Human Biomonitoring Data Introduction A physiologically based pharmacokinetic model for Hexamoll® diisononyl-cyclohexane-1, 2-dicarboxylate was developed to interpret the biokinetics in humans after single oral...
Learn more about the methodology developed by Professors W. Dekant and J.Bridges to make scientific evaluations more consistent when testing a hypothesis, using predefined criteria. Our factsheet allows you to grasp the most important points and data about QWoE at a glimpse. > FACTSHEET ...