ABSTRACT Hazard assessment of chemicals usually applies narrative assessments with a number of weaknesses. Therefore, application of weight of evidence (WoE) approaches are often mandated but guidance to perform a WoE assessment is lacking. This manuscript describes a quantitative WoE (QWoE) assessment for reproductive toxicity data...
ABSTRACT Quantitative weight of evidence (QWoE) methodology utilizes detailed scoring sheets to assess the quality/reliability of each publication on toxicity of a chemical and gives numerical scores for quality and observed toxicity. This QWoE-methodology was applied to the reproductive toxicity data on diisononylphthalate (DINP), di-n-hexylphthalate (DnHP),...
Introduction Phthalates are used in cosmetics, flooring adhesives, medical tubings, toys, food packaging materials, and so forth. A number of reviews of the epidemiology of phthalates have been published with conflicting results. As also noted by previous reviewers, the phthalate epidemiology literature is very diverse. It...
INTRODUCTION European Plasticisers (formerly European Council for Plasticisers and Intermediates - ECPI) commissioned PE International to conduct an LCA study with the goal to setup a PlasticsEurope Eco-profile and Environmental Product Declaration (EPD) of the plasticiser Di-isononyl phthalate (DINP). A critical review of the study was...